PPIRE10097
Target Protein Information
| Protein_Name | Suppressor of cytokine signaling 2 |
|---|---|
| Protein_Sequence | MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV |
| Organism_Source | Homo sapiens |
| Functional_Classification | E3 ubiquitin ligase |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SOCS2 |
| UniProt_ID | O14508 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | GHR_pY595 |
|---|---|
| Peptide_Sequence | PVPDXTSIHIV |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)CC |
| Chemical_Modification | X5=phosphotyrosine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1134.30 |
|---|---|
| Aliphatic_Index | 123.63636 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.90909 |
| Charge_at_pH_7 | -0.91066 |
| Isoelectric_Point | 5.29226 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 437.98000 |
| X_logP_energy | -3.97360 |
Interaction Information
| Affinity | KD=1.1 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 6I5N |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. |
| Release_Year | 2019 |
| PMID | 31182716 |
| DOI | 10.1038/s41467-019-10190-4 |