PPIRE10102

Target Protein Information
Protein_Name Galectin-8
Protein_Sequence MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
Organism_Source Homo sapiens
Functional_Classification lectins
Cellular_Localization Cytoplasm
Gene_Names LGALS8
UniProt_ID O00214
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NDP52_371-381
Peptide_Sequence QPGLAYGNPYS
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1166.26
Aliphatic_Index 44.54545
Aromaticity 0.18182
Average_Rotatable_Bonds 2.81818
Charge_at_pH_7 -0.00372
Isoelectric_Point 6.08660
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 483.61000
X_logP_energy -5.38270
Interaction Information
Affinity KD=5.2 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4GXL
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.
Release_Year 2013
PMID 23386746
DOI 10.1126/scisignal.2003730