PPIRE10107
Target Protein Information
| Protein_Name | Protein AF-9 |
|---|---|
| Protein_Sequence | MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS |
| Organism_Source | Homo sapiens |
| Functional_Classification | acetyllysine reader |
| Cellular_Localization | Nucleus |
| Gene_Names | MLLT3 |
| UniProt_ID | P42568 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H3(5-15)K9ac |
|---|---|
| Peptide_Sequence | QTARXSTGGKA |
| Peptide_Length | 11 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | X5=N-epsilon-acetyllysine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1033.11 |
|---|---|
| Aliphatic_Index | 18.18182 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.18182 |
| Charge_at_pH_7 | 1.99769 |
| Isoelectric_Point | 11.65178 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 20 |
| Topological_Polar_Surface_Area | 546.02000 |
| X_logP_energy | -10.40803 |
Interaction Information
| Affinity | KD=230 mM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 4TMP |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. |
| Release_Year | 2014 |
| PMID | 25417107 |
| DOI | 10.1016/j.cell.2014.09.049 |