PPIRE10216

Target Protein Information
Protein_Name Envelope glycoprotein
Protein_Sequence MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVNDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVSNGAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQSLTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPSATTAAGPPKAENTNTSKSTDFLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQNGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
Organism_Source Zaire ebolavirus (strain Eckron-76)
Functional_Classification viral envelope glycoproteins
Cellular_Localization Plasma membrane
Gene_Names GP
UniProt_ID P87671
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ebola virus GP peptide epitope
Peptide_Sequence VEQHHRRTDND
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1406.44
Aliphatic_Index 26.36364
Aromaticity 0.00000
Average_Rotatable_Bonds 4.27273
Charge_at_pH_7 -0.81754
Isoelectric_Point 6.50197
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 753.79000
X_logP_energy -10.30366
Interaction Information
Affinity IC50=3.5 uM
Affinity_Assay ELISA
PDB_ID 2QHR
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
Release_Year 2008
PMID 18005986
DOI 10.1016/j.jmb.2007.10.017