PPIRE10241

Target Protein Information
Protein_Name Delta-type opioid receptor
Protein_Sequence MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oprd1
UniProt_ID P33533
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Dimeric pentapeptide enkephalin(DPE2)
Peptide_Sequence YaGFLXYaGFL
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
Chemical_Modification X6=ethylenediamine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1178.35
Aliphatic_Index 89.09091
Aromaticity 0.36364
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.00372
Isoelectric_Point 6.08660
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 394.78000
X_logP_energy -0.34550
Interaction Information
Affinity KD=0.45 nM
Affinity_Assay Scatchard plot analysis
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Dimeric pentapeptide enkephalin: a novel probe of delta opiate receptors.
Release_Year 1982
PMID 6292643
DOI 10.1016/0024-3205(82)90055-8