PPIRE10244

Target Protein Information
Protein_Name Kappa-type opioid receptor
Protein_Sequence MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names OPRK1
UniProt_ID P41144
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name fI-Neo-endorphin
Peptide_Sequence YGGFLRKYPGQ
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1285.47
Aliphatic_Index 35.45455
Aromaticity 0.27273
Average_Rotatable_Bonds 3.54545
Charge_at_pH_7 1.99599
Isoelectric_Point 10.00862
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 517.00000
X_logP_energy -3.51013
Interaction Information
Affinity IC50=47.8 nM
Affinity_Assay in vitro bioassay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title [Leu5]enkephalin containing peptides derived from a common precursor: evaluation of opioid activity in in vitro bioassays.
Release_Year 1984
PMID 6327333
DOI 10.1016/0014-2999(84)90287-5