PPIRE10260

Target Protein Information
Protein_Name Calcitonin gene-related peptide type 1 receptor
Protein_Sequence MEKMCVLYFLFLLPFVMCLATAEPEEQSNDTMHLRVTRNKIMTAQYECYQKIMQDPVQQIEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICNKDGNWFRHPESNRTWTNYTQCNVNTPEKVKTALNLFYLTIIGHGLSITSLVISLGIFFYFKSLSCQRITLHKNLFFSFVCNSTVTIIHFTAVANNQALVATNPVSCKVSQFIHLYLLGCNYFWMLCEGIYLHTLIVVAVFAEKQHLIWYYFLGWGFPLIPACIHAIARSLYYNDNCWISFDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESHLYMKAVRATLILVPLLGIEFVLLPWRPEGRIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGHSFSHSDALRSASYTVSTISDGPGFSHDCASEHLNGKSIHDTDNMVLKPEKLKDLAI
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CALCRL
UniProt_ID H0UV86
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tyr CGRP(28-37)
Peptide_Sequence YVPTNVSGEAF
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1183.28
Aliphatic_Index 61.81818
Aromaticity 0.18182
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00109
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 486.61000
X_logP_energy -4.97990
Interaction Information
Affinity IC50=10 uM
Affinity_Assay radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Activities of calcitonin gene-related peptide (CGRP)and related peptides at the CGRP receptor.
Release_Year 1990
PMID 1696374
DOI 10.1016/0196-9781(90)90047-9