PPIRE10264

Target Protein Information
Protein_Name Somatostatin receptor type 1
Protein_Sequence MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR1
UniProt_ID P30872
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CH-275
Peptide_Sequence CKFFwXTFTSC
Peptide_Length 11
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O
Chemical_Modification X6=N-isopropylaminomethylphenylalanine
Cyclization_Method Side chain-side chain cyclization; C1<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1326.55
Aliphatic_Index 0.00000
Aromaticity 0.36364
Average_Rotatable_Bonds 3.45455
Charge_at_pH_7 0.87374
Isoelectric_Point 8.22969
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 456.82000
X_logP_energy -2.92770
Interaction Information
Affinity IC50=80 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: synthesis and characterization.
Release_Year 2004
PMID 15526334
DOI 10.1002/bip.20169