PPIRE10283

Target Protein Information
Protein_Name Mitochondrial import receptor subunit TOM20 homolog
Protein_Sequence MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
Organism_Source Rattus norvegicus
Functional_Classification mitochondrial protein import receptor
Cellular_Localization Mitochondrion
Gene_Names Tomm20
UniProt_ID Q62760
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pALDH(cxxC)L19S
Peptide_Sequence GcRLCRLSSYA
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; c2<->C5; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1228.45
Aliphatic_Index 80.00000
Aromaticity 0.09091
Average_Rotatable_Bonds 3.54545
Charge_at_pH_7 1.87318
Isoelectric_Point 8.80386
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 538.81000
X_logP_energy -6.69116
Interaction Information
Affinity KD=140 uM
Affinity_Assay NMR titration
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Release_Year 2011
PMID 21591667
DOI 10.1021/bi200470x