PPIRE10287

Target Protein Information
Protein_Name Growth factor receptor-bound protein 7
Protein_Sequence MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Organism_Source Homo sapiens
Functional_Classification adapter proteins
Cellular_Localization Cytoplasm
Gene_Names GRB7
UniProt_ID Q14451
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 08-6110
Peptide_Sequence PFSGYDNQFLC
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Main chain-side chain cyclization; N1<->C11; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Chloroacetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1290.41
Aliphatic_Index 35.45455
Aromaticity 0.27273
Average_Rotatable_Bonds 3.45455
Charge_at_pH_7 -1.06439
Isoelectric_Point 3.74997
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 504.27000
X_logP_energy -4.68010
Interaction Information
Affinity KD=44.25 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.
Release_Year 2011
PMID 21802427
DOI 10.1016/j.jmb.2011.07.030