PPIRE10292

Target Protein Information
Protein_Name Melanin-concentrating hormone receptor 1
Protein_Sequence MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MCHR1
UniProt_ID Q99705
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac-hMCH(6-16)-NH2
Peptide_Sequence RCMLGRVYRPC
Peptide_Length 11
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C2<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1353.68
Aliphatic_Index 61.81818
Aromaticity 0.09091
Average_Rotatable_Bonds 3.81818
Charge_at_pH_7 2.87317
Isoelectric_Point 9.59364
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 551.46000
X_logP_energy -4.56319
Interaction Information
Affinity IC50=0.17 nM
Affinity_Assay radioligand filter binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.
Release_Year 2002
PMID 11839762
DOI 10.1074/jbc.M200563200