PPIRE10360

Target Protein Information
Protein_Name Dynein light chain 1, cytoplasmic
Protein_Sequence MSDENKSTPIVKASDITDKLKEDILTISKDALDKYQLERDIAGTVKKQLDVKYGNTWHVIVGKNFGSYVTHEKGHFVYFYIGPLAFLVFKTA
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification dynein light chain
Cellular_Localization Cytoplasm
Gene_Names DYN2
UniProt_ID Q02647
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pac11 pep2
Peptide_Sequence ITYDKGIQTDQ
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1281.38
Aliphatic_Index 70.90909
Aromaticity 0.09091
Average_Rotatable_Bonds 3.90909
Charge_at_pH_7 -1.00227
Isoelectric_Point 4.10925
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 601.81000
X_logP_energy -6.71080
Interaction Information
Affinity KD=620 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4HT6
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization.
Release_Year 2013
PMID 23761070
DOI 10.1091/mbc.E13-03-0166