PPIRE10382

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification histone methyltransferase complex subunit
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cAzo-peptide
Peptide_Sequence SARAXVHLRKS
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X5=2-[[4-(Acetamido)phenyl]azo]-5,6-dihydrodibenzo[cg][1,2]diazocine-3-carboxylic acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1181.36
Aliphatic_Index 80.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.63636
Charge_at_pH_7 3.08859
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 573.28000
X_logP_energy -7.77446
Interaction Information
Affinity Ki=140 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 6IAM
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches.
Release_Year 2018
PMID 30675988
DOI 10.1002/cbic.201800737