PPIRE10411

Target Protein Information
Protein_Name Circumsporozoite protein
Protein_Sequence EALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANGNNAVKNNNNEEPSDQHIEKYL
Organism_Source Plasmodium falciparum (isolate le5)
Functional_Classification surface proteins
Cellular_Localization Extracellular
Gene_Names CSP
UniProt_ID P05691
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (NPNA)3
Peptide_Sequence NPNANPNANPNA
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1207.22
Aliphatic_Index 25.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.66667
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 615.59000
X_logP_energy -11.43820
Interaction Information
Affinity KD=0.305 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6AXK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Release_Year 2017
PMID 29138320
DOI 10.1073/pnas.1715812114