PPIRE10414

Target Protein Information
Protein_Name Circumsporozoite protein
Protein_Sequence EALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANGNNAVKNNNNEEPSDQHIEKYL
Organism_Source Plasmodium falciparum (isolate le5)
Functional_Classification surface proteins
Cellular_Localization Extracellular
Gene_Names CSP
UniProt_ID P05691
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NPNVDPNANPNV
Peptide_Sequence NPNVDPNANPNV
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1264.32
Aliphatic_Index 56.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.83333
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 609.80000
X_logP_energy -9.56670
Interaction Information
Affinity KD=12.091 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Release_Year 2017
PMID 29138320
DOI 10.1073/pnas.1715812114