PPIRE10422
Target Protein Information
| Protein_Name | Eukaryotic translation initiation factor 2-alpha kinase 3 |
|---|---|
| Protein_Sequence | MERATGPGSLARTLLLPLLLGLVAGTVTARRTSDLLAPTAEAAFGLGAAAAPTSATRVPATGAVIAAEVTVEDSEALPAAAGEQEAREPEPEPEEEPDIRPCGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDNDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTLKPSGNKEQSKIISDVEEQEAVMMDTVIKVSVADWKVMAFNKKGGHLEWEYQFCTPIASAWLVKDGKVIPISLFDDTSYAPNDGVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPTSPKALESVSSENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPNYKNIRKKDPVLLLHWWKEIVGTIVFCIVATTFIVRRLFHPHPHRQRKESETQCQTENKYDAVSGEANDSSWNDIKNSGYVSRYLTDFEPIQCMGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDDSTDWPLSSPSPVDAPSVKIRRMDPFSTKECIEIIAPSPHSSRSFSVGISCSQTSSSESQFSPLEFSGMDHGNVSKSADAVCQLQDSCLTDCEGEDGTMDGNDEGHSFELCPSEASPYIRSRERTSSSIVFEDSGCDNASSKEEPRMNQPPVGNHYANKLSALRHSGSKSSEPTVSVSPSRPTTLSLDLTKSSVGKLQPSSPKVYLYIQMQLCRKENLKDWLNSRCTIEARERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEDQMVLTPMPGYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFGTQMERVRILTDVRDLKFPPLFAQKYPREYAMVQDMLSPSPTERPEAASIIENAIFEDLEFPEKTLLRQRSRSMSSPGAKHSRHSSSPHSPLPSN |
| Organism_Source | Bos taurus |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | EIF2AK3 |
| UniProt_ID | A5D791 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | P16 |
|---|---|
| Peptide_Sequence | ADPQPWRFYAPR |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1503.68 |
|---|---|
| Aliphatic_Index | 16.66667 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | 0.99757 |
| Isoelectric_Point | 9.34763 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 20 |
| Topological_Polar_Surface_Area | 597.26000 |
| X_logP_energy | -3.52876 |
Interaction Information
| Affinity | KD=0.2 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 5V1D |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization. |
| Release_Year | 2018 |
| PMID | 29386355 |
| DOI | 10.1074/jbc.RA117.001294 |