PPIRE10452

Target Protein Information
Protein_Name Inhibitor of growth protein 1
Protein_Sequence MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
Organism_Source Homo sapiens
Functional_Classification histone methylation reader
Cellular_Localization Nucleus
Gene_Names ING1
UniProt_ID Q9UK53
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Histone H3(1-12)K4me1 peptide
Peptide_Sequence ARTKQTARKSTG
Peptide_Length 12
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification K4=monomethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1304.47
Aliphatic_Index 16.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 683.27000
X_logP_energy -11.41296
Interaction Information
Affinity KD=419 uM
Affinity_Assay NMR
PDB_ID 2QIC
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
Release_Year 2008
PMID 18533182
DOI 10.1016/j.jmb.2008.04.061