PPIRE10472
Target Protein Information
| Protein_Name | Macrophage scavenger receptor types I and II |
|---|---|
| Protein_Sequence | MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS |
| Organism_Source | Mus musculus |
| Functional_Classification | scavenger receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Msr1 |
| UniProt_ID | P30204 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | PEG30 kDa-Cys-Trp-Lys10 |
|---|---|
| Peptide_Sequence | CWKKKKKKKKKK |
| Peptide_Length | 12 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CS)C(=O)O |
| Chemical_Modification | C1=maleimide-PEG30kDa |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Pegylation |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1589.11 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 5.50000 |
| Charge_at_pH_7 | 9.93306 |
| Isoelectric_Point | 11.40283 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 24 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 659.41000 |
| X_logP_energy | -3.32510 |
Interaction Information
| Affinity | IC50=20.1 uM |
|---|---|
| Affinity_Assay | in vivo gamma-counting biodistribution assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure-Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery. |
| Release_Year | 2015 |
| PMID | 26485572 |
| DOI | 10.1021/acs.molpharmaceut.5b00513 |