PPIRE10473

Target Protein Information
Protein_Name Myc proto-oncogene protein
Protein_Sequence MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
Organism_Source Homo sapiens
Functional_Classification basic helix-loop-helix leucine zipper
Cellular_Localization Nucleus
Gene_Names MYC
UniProt_ID P01106
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HIV Tat peptide
Peptide_Sequence CYGRKKRRQRRR
Peptide_Length 12
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1662.99
Aliphatic_Index 0.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 5.08333
Charge_at_pH_7 7.93455
Isoelectric_Point 12.51220
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 870.18000
X_logP_energy -10.65628
Interaction Information
Affinity IC50=25 mM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.
Release_Year 2003
PMID 12691534
DOI 10.1089/108729003764097322