PPIRE10481

Target Protein Information
Protein_Name Anthrax toxin receptor 1
Protein_Sequence MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
Organism_Source Homo sapiens
Functional_Classification cell surface receptors
Cellular_Localization Plasma membrane
Gene_Names ANTXR1
UniProt_ID Q9H6X2
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ABP 2
Peptide_Sequence DSFNGRYEHVPH
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1457.52
Aliphatic_Index 24.16667
Aromaticity 0.16667
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 -0.81883
Isoelectric_Point 6.49966
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 652.04000
X_logP_energy -6.88223
Interaction Information
Affinity KD=67 nM
Affinity_Assay fluorescence binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of a receptor-based inhibitory penta-unit-conjugated peptide to enhance anthrax toxin neutralization.
Release_Year 2020
PMID 32619663
DOI 10.1016/j.ijbiomac.2020.06.264