PPIRE10486

Target Protein Information
Protein_Name Cholesteryl ester transfer protein
Protein_Sequence MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
Organism_Source Homo sapiens
Functional_Classification lipid transfer protein
Cellular_Localization Extracellular
Gene_Names CETP
UniProt_ID P11597
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SBH-peptide
Peptide_Sequence EHLLVDFLQSLS
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1400.59
Aliphatic_Index 154.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 -1.90889
Isoelectric_Point 4.18115
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 570.25000
X_logP_energy -3.63040
Interaction Information
Affinity KD=10.5 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational derivation of CETP self-binding helical peptides by Pi-Pi stacking and halogen bonding: Therapeutic implication for atherosclerosis.
Release_Year 2016
PMID 27611728
DOI 10.1016/j.bioorg.2016.08.012