PPIRE10490

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2B
Protein_Sequence KTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification IgG2b
Cellular_Localization Extracellular
Gene_Names Ighg2b
UniProt_ID P01867
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BsRNaseY(79-90)peptide
Peptide_Sequence ERRNELQKQENR
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1599.73
Aliphatic_Index 32.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.00000
Charge_at_pH_7 1.00300
Isoelectric_Point 9.68541
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 879.40000
X_logP_energy -11.42779
Interaction Information
Affinity KD=0.36 nM
Affinity_Assay ELISA
PDB_ID 6F7T
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding.
Release_Year 2018
PMID 30447990
DOI 10.1016/j.bpj.2018.10.016