PPIRE10505

Target Protein Information
Protein_Name EH domain-containing protein 1
Protein_Sequence MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
Organism_Source Homo sapiens
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names EHD1
UniProt_ID Q9H4M9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EHD1 GPF wild-type peptide
Peptide_Sequence FDGTMNGPFGHG
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1236.32
Aliphatic_Index 0.00000
Aromaticity 0.16667
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.91066
Isoelectric_Point 5.29226
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 503.93000
X_logP_energy -6.30190
Interaction Information
Affinity KD=2.3 mM
Affinity_Assay NMR chemical shift titration (15N-HSQC)
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.
Release_Year 2009
PMID 19798736
DOI 10.1002/pro.258