PPIRE10521

Target Protein Information
Protein_Name EH domain-containing protein 1
Protein_Sequence MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
Organism_Source Homo sapiens
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names EHD1
UniProt_ID Q9H4M9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Rab11-FIP2 GPF peptide
Peptide_Sequence FNYESTGPFTAK
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1361.47
Aliphatic_Index 8.33333
Aromaticity 0.25000
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 -0.00139
Isoelectric_Point 6.40200
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 561.96000
X_logP_energy -6.05460
Interaction Information
Affinity KD=2.4 mM
Affinity_Assay NMR chemical shift titration (15N-HSQC)
PDB_ID 2KFH
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.
Release_Year 2009
PMID 19798736
DOI 10.1002/pro.258