PPIRE10535

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification WD40 repeat proteins
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SET1BWin
Peptide_Sequence GGARSEHYFPRR
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1432.56
Aliphatic_Index 8.33333
Aromaticity 0.16667
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 2.08981
Isoelectric_Point 11.05370
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 666.77000
X_logP_energy -7.67629
Interaction Information
Affinity KD=0.1 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3UVK
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.
Release_Year 2012
PMID 22266653
DOI 10.1093/nar/gkr1235