PPIRE10541

Target Protein Information
Protein_Name Importin subunit alpha-5
Protein_Sequence MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL
Organism_Source Mus musculus
Functional_Classification nuclear transport receptor
Cellular_Localization Cytoplasm
Gene_Names Kpna1
UniProt_ID Q60960
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pUL15 NLS
Peptide_Sequence GPPKKRAKVDVA
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CN)C(C)C)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1265.52
Aliphatic_Index 65.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.41667
Charge_at_pH_7 2.99754
Isoelectric_Point 11.07952
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 543.10000
X_logP_energy -5.14833
Interaction Information
Affinity KD=10 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5HUW
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.
Release_Year 2016
PMID 27033706
DOI 10.1074/jbc.M116.724393