PPIRE10567

Target Protein Information
Protein_Name Kelch domain-containing protein 2
Protein_Sequence MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS
Organism_Source Homo sapiens
Functional_Classification ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names KLHDC2
UniProt_ID Q9Y2U9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SelK C-end degron(12 aa)
Peptide_Sequence HLRGSPPPMAGG
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1176.36
Aliphatic_Index 40.83333
Aromaticity 0.00000
Average_Rotatable_Bonds 2.66667
Charge_at_pH_7 1.08889
Isoelectric_Point 10.55176
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 467.86000
X_logP_energy -5.81563
Interaction Information
Affinity KD=3.75 nM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.
Release_Year 2018
PMID 30526872
DOI 10.1016/j.molcel.2018.10.021