PPIRE10571

Target Protein Information
Protein_Name Tyrosine-protein kinase HCK
Protein_Sequence MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Organism_Source Homo sapiens
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names HCK
UniProt_ID P08631
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PD1
Peptide_Sequence HSKYPLPPLPSL
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1348.61
Aliphatic_Index 97.50000
Aromaticity 0.08333
Average_Rotatable_Bonds 2.91667
Charge_at_pH_7 1.08775
Isoelectric_Point 9.30070
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 463.65000
X_logP_energy -2.07810
Interaction Information
Affinity KD=0.23 uM
Affinity_Assay fluorescence titration
PDB_ID 2A4Y
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.
Release_Year 2007
PMID 17141806
DOI 10.1016/j.jmb.2006.11.013