PPIRE10587

Target Protein Information
Protein_Name None
Protein_Sequence MAMTKKFKVSFDVTAKMSSDVQAILEKDMLHLCKQVGSGAIVPNGKQKEMIVQFLTHGMEGLMTFVVRTSFREAIKDMHEEYADKDSFKQSSATVREVF
Organism_Source Escherichia phage T7
Functional_Classification DNA polymerases
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q6WY88
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TP-2
Peptide_Sequence SRNVNCNASVCTIPDRLITDNPGSGS
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2690.94
Aliphatic_Index 71.15385
Aromaticity 0.00000
Average_Rotatable_Bonds 3.26923
Charge_at_pH_7 -0.12508
Isoelectric_Point 6.17585
Number_of_Hydrogen_Bond_Acceptors 43
Number_of_Hydrogen_Bond_Donors 45
Topological_Polar_Surface_Area 1265.38000
X_logP_energy -21.16836
Interaction Information
Affinity IC50=10 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin.
Release_Year 2008
PMID 18672101
DOI 10.1016/j.bbapap.2008.06.022