PPIRE10606
Target Protein Information
| Protein_Name | Eukaryotic translation initiation factor 4E |
|---|---|
| Protein_Sequence | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV |
| Organism_Source | Homo sapiens |
| Functional_Classification | translation initiation factor |
| Cellular_Localization | Cytoplasm |
| Gene_Names | EIF4E |
| UniProt_ID | P06730 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | VL-PHAGESOL-Q8F |
|---|---|
| Peptide_Sequence | KKRYSRDFLLAL |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1509.81 |
|---|---|
| Aliphatic_Index | 105.83333 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 4.33333 |
| Charge_at_pH_7 | 2.99698 |
| Isoelectric_Point | 10.88576 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 637.02000 |
| X_logP_energy | -3.66816 |
Interaction Information
| Affinity | KD=49.6 nM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects. |
| Release_Year | 2012 |
| PMID | 23094039 |
| DOI | 10.1371/journal.pone.0047235 |