PPIRE10701

Target Protein Information
Protein_Name Importin subunit alpha-5
Protein_Sequence MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL
Organism_Source Mus musculus
Functional_Classification nuclear transport receptor
Cellular_Localization Cytoplasm
Gene_Names Kpna1
UniProt_ID Q60960
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SV40 NLS
Peptide_Sequence PKKKRKVEDPYC
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1490.78
Aliphatic_Index 24.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 2.93620
Isoelectric_Point 10.04100
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 621.45000
X_logP_energy -4.68513
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3Q5U
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.
Release_Year 2016
PMID 27033706
DOI 10.1074/jbc.M116.724393