PPIRE10731

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
Organism_Source Homo sapiens
Functional_Classification karyopherins
Cellular_Localization Cytoplasm
Gene_Names KPNA2
UniProt_ID P52292
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Vpr85-96
Peptide_Sequence QQRRTRNGASKS
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1388.51
Aliphatic_Index 8.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 4.16667
Charge_at_pH_7 3.99768
Isoelectric_Point 12.80743
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 785.10000
X_logP_energy -13.92699
Interaction Information
Affinity KD=30 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5B56
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular Mechanism of HIV-1 Vpr for Binding to Importin-Alpha.
Release_Year 2016
PMID 27181198
DOI 10.1016/j.jmb.2016.05.003