PPIRE10756

Target Protein Information
Protein_Name Low density lipoprotein receptor adapter protein 1
Protein_Sequence MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTAQMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTSVATGNLLDLEELAKAPLSTVSANTKNMDDALRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDIHYAQCLSPTDWDKPDSSGFDQDDVFSF
Organism_Source Rattus norvegicus
Functional_Classification endocytic adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names Ldlrap1
UniProt_ID D3ZAR1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LDLR tail
Peptide_Sequence SINFDNPVYQKT
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Biotin-Peg8
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1425.56
Aliphatic_Index 56.66667
Aromaticity 0.16667
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -0.00271
Isoelectric_Point 6.33059
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 627.91000
X_logP_energy -6.87650
Interaction Information
Affinity KD=4 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 3SO6
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Release_Year 2012
PMID 22509010
DOI 10.1073/pnas.1114128109