PPIRE10770

Target Protein Information
Protein_Name Peroxisomal membrane protein PEX14
Protein_Sequence MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
Organism_Source Homo sapiens
Functional_Classification peroxisomal import receptor
Cellular_Localization Cytoplasm
Gene_Names PEX14
UniProt_ID O75381
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pex19(66-77)
Peptide_Sequence SQEKFFQELFDS
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1504.62
Aliphatic_Index 32.50000
Aromaticity 0.25000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 -1.99831
Isoelectric_Point 3.92755
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 647.98000
X_logP_energy -5.64580
Interaction Information
Affinity KD=9 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2W85
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Release_Year 2009
PMID 19197237
DOI 10.1038/emboj.2009.7