PPIRE10794

Target Protein Information
Protein_Name Polycomb protein EED
Protein_Sequence MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
Organism_Source Homo sapiens
Functional_Classification WD40 repeat proteins
Cellular_Localization Nucleus
Gene_Names EED
UniProt_ID O75530
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name K27
Peptide_Sequence TKAARXSAPATY
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification X6=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1193.33
Aliphatic_Index 33.33333
Aromaticity 0.08333
Average_Rotatable_Bonds 2.91667
Charge_at_pH_7 1.99684
Isoelectric_Point 10.45492
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 543.47000
X_logP_energy -7.95723
Interaction Information
Affinity KD=45.6 uM
Affinity_Assay fluorescence competition assay
PDB_ID 3IIW
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Role of the polycomb protein EED in the propagation of repressive histone marks.
Release_Year 2009
PMID 19767730
DOI 10.1038/nature08398