PPIRE10798

Target Protein Information
Protein_Name UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
Protein_Sequence MPSIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGANAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTIYHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHNVVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVMNIDDMSKRLKSLERKVNQQD
Organism_Source Escherichia coli O157:H7
Functional_Classification acyltransferases
Cellular_Localization Cytoplasm
Gene_Names lpxD
UniProt_ID P65323
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FITC-RJPXD33
Peptide_Sequence TNLYMLPKWDIP
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein Isothiocyanate
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1490.78
Aliphatic_Index 97.50000
Aromaticity 0.16667
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 -0.00271
Isoelectric_Point 6.33059
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 528.50000
X_logP_energy -0.83290
Interaction Information
Affinity KD=0.6 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.
Release_Year 2014
PMID 24742680
DOI 10.1074/jbc.M114.564278