PPIRE10805

Target Protein Information
Protein_Name Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Protein_Sequence MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR
Organism_Source Escherichia coli (strain K12)
Functional_Classification acyltransferases
Cellular_Localization Cytoplasm
Gene_Names lpxA
UniProt_ID P0A722
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FITC-Photo1
Peptide_Sequence TNXYMLPKWDIP
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification X3=photo-leucine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein Isothiocyanate
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1434.67
Aliphatic_Index 65.00000
Aromaticity 0.16667
Average_Rotatable_Bonds 3.41667
Charge_at_pH_7 -0.00271
Isoelectric_Point 6.33059
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 528.50000
X_logP_energy -2.24760
Interaction Information
Affinity KD=50 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 4J09
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.
Release_Year 2014
PMID 24742680
DOI 10.1074/jbc.M114.564278