PPIRE10898

Target Protein Information
Protein_Name None
Protein_Sequence MSKNKINTTSATAASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINNDDNFGRALKTARPLLRVIVQRKDDLNEYSGFGTMKPRNLIGSILMGHTPVKTKAPSISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRNSQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTGVTLDESPTSTSAGNHNHQPPLSSSPSSHHQQAASNASTIMASDVKDGVLHL
Organism_Source Drosophila melanogaster
Functional_Classification scaffolding proteins
Cellular_Localization Plasma membrane
Gene_Names par-6
UniProt_ID O97111
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pals1(29-40)
Peptide_Sequence YPKHREMAVDCP
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1445.67
Aliphatic_Index 32.50000
Aromaticity 0.08333
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 0.02799
Isoelectric_Point 7.35654
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 577.27000
X_logP_energy -4.25183
Interaction Information
Affinity KD=8 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.
Release_Year 2004
PMID 15475968
DOI 10.1038/nsmb839