PPIRE10932

Target Protein Information
Protein_Name Coagulation factor VII
Protein_Sequence MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Organism_Source Homo sapiens
Functional_Classification serine proteases
Cellular_Localization Extracellular
Gene_Names F7
UniProt_ID P08709
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FVII EGF-2 loop I cyclic peptide(91-102)
Peptide_Sequence CVNENGGCEQYC
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1318.41
Aliphatic_Index 24.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -2.18524
Isoelectric_Point 3.61366
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 607.52000
X_logP_energy -8.86650
Interaction Information
Affinity IC50=350 uM
Affinity_Assay Affinity chromatography
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A peptide sequence from the EGF-2 like domain of FVII inhibits TF-dependent FX activation.
Release_Year 1997
PMID 9172287
DOI 10.1016/S0049-3848(97)00045-5