PPIRE10936

Target Protein Information
Protein_Name CHRNA7-FAM7A fusion protein
Protein_Sequence MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification ligand-gated ion channels
Cellular_Localization Plasma membrane
Gene_Names CHRFAM7A
UniProt_ID Q494W8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Conotoxin ImI
Peptide_Sequence GCCSDPRCGWRC
Peptide_Length 12
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain; C2<->C8; disulfide bond; C3<->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amidated
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1342.55
Aliphatic_Index 0.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.75053
Isoelectric_Point 7.91689
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 571.75000
X_logP_energy -8.06316
Interaction Information
Affinity IC50=232 nM
Affinity_Assay electrophysiology
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.
Release_Year 2006
PMID 16505382
DOI 10.1073/pnas.0507889103