PPIRE10947

Target Protein Information
Protein_Name Eukaryotic translation initiation factor 4E
Protein_Sequence MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Organism_Source Homo sapiens
Functional_Classification translation initiation factors
Cellular_Localization Cytoplasm
Gene_Names EIF4E
UniProt_ID P06730
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name sTIP-04
Peptide_Sequence KKRYSRXQLLXL
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification X7=(S)-2-(4-pentenyl)alanine; X11=(R)-2-(4-pentenyl)alanine
Cyclization_Method side chain-side chain cyclization; X7<->X11; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1418.71
Aliphatic_Index 97.50000
Aromaticity 0.08333
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 3.99654
Isoelectric_Point 11.67668
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 642.81000
X_logP_energy -5.87716
Interaction Information
Affinity KD=11.5 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 4BEA
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces.
Release_Year 2013
PMID 24336354
DOI 10.1038/srep03451