PPIRE10957

Target Protein Information
Protein_Name Somatostatin receptor type 1
Protein_Sequence MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR1
UniProt_ID P30872
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Compound 14
Peptide_Sequence YCKFFwXTFTSC
Peptide_Length 12
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O
Chemical_Modification X7=4-(N-isopropyl)-aminomethylphenylalanine
Cyclization_Method Side chain-side chain cyclization; C2<->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1489.73
Aliphatic_Index 0.00000
Aromaticity 0.41667
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.87289
Isoelectric_Point 8.22117
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 506.15000
X_logP_energy -2.49460
Interaction Information
Affinity IC50=14 nM
Affinity_Assay receptor autoradiography
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.
Release_Year 2005
PMID 15658865
DOI 10.1021/jm049519m