PPIRE10969

Target Protein Information
Protein_Name CHRNA7-FAM7A fusion protein
Protein_Sequence MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification ligand-gated ion channel
Cellular_Localization Plasma membrane
Gene_Names CHRFAM7A
UniProt_ID Q494W8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ImI1(bicyclic 1)
Peptide_Sequence GXASDPRCAWRC
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)CNC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification X2=(4S)-L-4-5-dithiolnorvaline
Cyclization_Method Side chain cyclization; X2<->C8; disulfide bond; X2<->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1278.43
Aliphatic_Index 16.66667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.08333
Charge_at_pH_7 0.87447
Isoelectric_Point 8.23140
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 571.75000
X_logP_energy -7.88296
Interaction Information
Affinity IC50=0.05 uM
Affinity_Assay voltage clamp
PDB_ID 2MOA
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Release_Year 2014
PMID 25343607
DOI 10.1038/NCHEM.2043