PPIRE10976

Target Protein Information
Protein_Name Histone-binding protein RBBP4
Protein_Sequence MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Organism_Source Homo sapiens
Functional_Classification chromatin remodeling complex component
Cellular_Localization Nucleus
Gene_Names RBBP4
UniProt_ID Q09028
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AEBP2_379-390 peptide
Peptide_Sequence KRRKLKNKRRRS
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1625.99
Aliphatic_Index 32.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.33333
Charge_at_pH_7 8.99679
Isoelectric_Point 13.11267
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 860.32000
X_logP_energy -10.52275
Interaction Information
Affinity KD=7.6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4.
Release_Year 2017
PMID 29134516
DOI 10.1007/s13238-017-0483-6