PPIRE10984

Target Protein Information
Protein_Name PHD finger protein 1
Protein_Sequence MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
Organism_Source Homo sapiens
Functional_Classification chromatin readers
Cellular_Localization Nucleus
Gene_Names PHF1
UniProt_ID O43189
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3(29-41)K36me3
Peptide_Sequence APATGGVKKPHRY
Peptide_Length 13
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification K8=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1381.60
Aliphatic_Index 37.69231
Aromaticity 0.07692
Average_Rotatable_Bonds 3.15385
Charge_at_pH_7 3.08745
Isoelectric_Point 10.90184
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 578.02000
X_logP_energy -5.99693
Interaction Information
Affinity KD=2 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5XFQ
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Polycomb-like proteins link the PRC2 complex to CpG islands.
Release_Year 2017
PMID 28869966
DOI 10.1038/nature23881