PPIRE11021

Target Protein Information
Protein_Name E3 ubiquitin-protein ligase SIAH1
Protein_Sequence MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
Organism_Source Homo sapiens
Functional_Classification ubiquitin protein ligases
Cellular_Localization Cytoplasm
Gene_Names SIAH1
UniProt_ID Q8IUQ4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SIP(58-70)peptide
Peptide_Sequence EKPAAVVAPITTG
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1253.46
Aliphatic_Index 97.69231
Aromaticity 0.00000
Average_Rotatable_Bonds 2.76923
Charge_at_pH_7 -0.00054
Isoelectric_Point 6.40880
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 498.72000
X_logP_energy -4.96710
Interaction Information
Affinity KD=24 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2A25
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.
Release_Year 2005
PMID 16085652
DOI 10.1074/jbc.M506707200