PPIRE11039

Target Protein Information
Protein_Name Protein AF-9
Protein_Sequence MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
Organism_Source Homo sapiens
Functional_Classification YEATS domain
Cellular_Localization Nucleus
Gene_Names MLLT3
UniProt_ID P42568
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K18ac peptide
Peptide_Sequence GGKAPRXQLATKA
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification X7=acetyl-lysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1254.45
Aliphatic_Index 53.07692
Aromaticity 0.00000
Average_Rotatable_Bonds 3.23077
Charge_at_pH_7 2.99739
Isoelectric_Point 11.82306
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 580.99000
X_logP_energy -8.11033
Interaction Information
Affinity KD=59.5 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2NDF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Release_Year 2016
PMID 27545619
DOI 10.1016/j.str.2016.05.023