PPIRE11057

Target Protein Information
Protein_Name Fusion glycoprotein F0
Protein_Sequence MELPILKANAITTILAAVTFCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLINQELDKYKNAVTELQLLMQSTTAANNRARRELPRFMNYTLNNTKKTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCRISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHHVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
Organism_Source Human respiratory syncytial virus
Functional_Classification viral fusion glycoproteins
Cellular_Localization Extracellular
Gene_Names F
UniProt_ID P12568
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Nh1
Peptide_Sequence GVSVLTSKVLDLK
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1358.64
Aliphatic_Index 156.92308
Aromaticity 0.00000
Average_Rotatable_Bonds 3.61538
Charge_at_pH_7 0.99784
Isoelectric_Point 9.53730
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 562.55000
X_logP_energy -4.94830
Interaction Information
Affinity KD=830 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 1G2C
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Targeting the membrane fusion event of human respiratory syncytial virus with rationally designed Alpha-helical hairpin traps.
Release_Year 2021
PMID 34111463
DOI 10.1016/j.lfs.2021.119695