PPIRE11078

Target Protein Information
Protein_Name Vitamin D3 receptor
Protein_Sequence MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
Organism_Source Rattus norvegicus
Functional_Classification nuclear hormone receptors
Cellular_Localization Nucleus
Gene_Names Vdr
UniProt_ID P13053
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SRC2-3
Peptide_Sequence KENALLRYLLDKD
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1590.84
Aliphatic_Index 127.69231
Aromaticity 0.07692
Average_Rotatable_Bonds 4.30769
Charge_at_pH_7 -0.00079
Isoelectric_Point 6.54749
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 701.68000
X_logP_energy -4.42063
Interaction Information
Affinity KD=0.029 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 5H1E
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity.
Release_Year 2017
PMID 27890450
DOI 10.1016/j.bmc.2016.11.020