PPIRE11088

Target Protein Information
Protein_Name Myosin light chain kinase, smooth muscle
Protein_Sequence FIVLSQEGSLCSISIEKALPEDRGLYKCVAKNSAGQAECSCQVTVDDAPTGENAKAPEMKARRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVAGTQPITCTWMKFRKQIQES
Organism_Source Sus scrofa
Functional_Classification kinases
Cellular_Localization Cytoplasm
Gene_Names MYLK
UniProt_ID P79280
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 7
Peptide_Sequence KKRAARATSNVFA
Peptide_Length 13
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1419.65
Aliphatic_Index 53.07692
Aromaticity 0.07692
Average_Rotatable_Bonds 3.69231
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 671.91000
X_logP_energy -8.77276
Interaction Information
Affinity IC50=900 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides.
Release_Year 1989
PMID 2920029
DOI 10.1042/bj2570073